Rivnuts from Homestead, PA on 4/4/2024 7:26:25 PM:
First of all, late September is an ideal time to ride the GAP/C&O in my opinion.
While there is an Enterprise Car Rental location in downtown Pittsburgh at 55 11th Street (about 1/2 mile from Point State Park and the start of the GAP Trail) which is at the Greyhound Bus Station, I don't know if they will accept a one-way rental. I ride past there often. I'll stop there the next time I go past and inquire and let you know what they say.
The Pittsburgh Regional Transit (PRT) System operates a route (so called 28X route) from the airport to downtown (corner of Liberty and Wood Streets) with only one stop in route. This location is even closer to Point State Park than the bus station, say, 1/4 mile. All the PRT buses are equipped with bike racks. Buses leave the airport every half hour for the 35-minute trip to downtown. The trip to town costs $2.75. Tickets are available near Baggage Claim Door 2 on the lower level of the terminal.
If I can provide any additional information about Pittsburgh or the GAP/C&O, just drop a note.