Angie from central PA on 8/22/2013 12:14:32 AM:
My husband and I just finished riding the trail. He is originally from that area, and I recognized route 219 when we stopped in Meyersdale. It goes straight through Meyersdale and traveling north will take you to Johnstown.
Meyersdale is large enough for a visitors center on the trail, which is accessible by car for a pickup. I would think it would be easy to get google map directions from where ever your wife will be prior to picking you up to the Meyersdale visitors center. If no address can be found for the visitor center, entering town on 219 and taking main street north-east will get you to the center.
People seemed very friendly in town, so if lost, asking around would get you straightened out.